Caspian Journal of Veterinary Sciences

Caspian Journal of Veterinary Sciences

Antimicrobial peptides and their importance in aquaculture

Document Type : Review article

Authors
1 Department of Clinical Science, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
2 Department of Pathobiology, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
Abstract
Intensive fish culture plays an essential role in fish health. The high fish density and unfavourable conditions of water quality factors are potential sources of stress in fish, which often predispose fish to diseases. Infected fish are usually treated using antibiotics, which are not always effective, and the accumulation of these compounds in fish meat endangers the consumers' health. In addition, the excessive use of antibiotics has caused the emergence of antibiotic-resistant pathogens which accounts for a major financial threat to the aquaculture industry. Fish antimicrobial peptides (AMPs) can potentially replace conventional commercial antibiotics in the aquaculture industry due to a wide range of antimicrobial activity, potential of boosting the immune system, and activity at different temperatures and salinities. Therefore, introducing new antimicrobial compounds to treat fish diseases can greatly contribute to the aquaculture industry.
Keywords

Brogden KA (2005). Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol., 3:
238-250.
Brown KL and Hancock RE (2006). Cationic host defense
(antimicrobial) peptides. Curr. Opin. Immunol., 18: 24-30.
Casadei E (2011). The effect of dietary immunostimulation on
antimicrobial peptide expression in rainbow trout
(Oncorhynchus mykiss) and their potential role in defence
against pathogens (Doctoral dissertation, University of
Aberdeen).
Dawood MA, Koshio S, Ishikawa M and Yokoyama S
(2015). Effects of heat killed Lactobacillus plantarum
(LP20) supplemental diets on growth performance, stress
resistance and immune response of red sea bream,
Pagrus. major. Aquac., 442: 29-36.
Dawood, MA (2021). Nutritional immunity of fish intestines:
Important insights for sustainable aquaculture. Rev.
Aquac., 13: 642-663.
Douglas SE (2011). Antimicrobial peptides and their
potential as therapeutants in aquaculture. Aquac.
Biotechnol., 105-120.
FAO (2022). The State of World Fisheries and Aquaculture.
Towards Blue Transformation.1th ed. FAO. Rome, Italy.
Frank RW, Gennaro RE, Schneider K, Przybylski M and
Romeo D (1990). Amino acid sequences of two prolinerich bactenecins. Antimicrobial peptides of bovine
neutrophils. JBC., 265: 18871-18874.
Garvey M (2023). Antimicrobial Peptides Demonstrate
Activity against Resistant Bacterial Pathogens. Infect. Dis.
Rep., 15: 454-469.
Hancock RE and Sahl HG (2006). Antimicrobial and hostdefense peptides as new anti-infective therapeutic
strategies. Nat. Biotechnol., 24: 1551-1557.
Heilborn JD, Nilsson MF, Sørensen O, Ståhle-Bäckdahl M,
Kratz G, Weber G and Borregaard N (2003). The
cathelicidin anti-microbial peptide LL-37 is involved in reepithelialization of human skin wounds and is lacking in
chronic ulcer epithelium. JID., 120: 379-389.
Heuer OE, Kruse H, Grave K, Collignon P, Karunasagar I
and Angulo FJ (2009). Human health consequences of
use of antimicrobial agents in aquaculture. Clin. Infect.
Dis., 49: 1248-1253.
Hirono I, Hwang JY, Ono Y, Kurobe T, Ohira T, Nozaki R
and Aoki T (2005). Two different types of hepcidins from
the Japanese flounder Paralichthys olivaceus. FEBS. J.,
272: 5257-5264.
Ingham AB and Moore RJ (2007). Recombinant production
of antimicrobial peptides in heterologous microbial
systems. Biotechnol. Appl. Biochem., 47: 1-9.
Katzenback BA, (2015). Antimicrobial peptides as mediators
of innate immunity in teleosts. Biol., 4: 607-639.
Lai Y and Gallo RL (2009). AMPed up immunity: how
antimicrobial peptides have multiple roles in immune
defense. Trends Immunol., 30: 131-141.
Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg
JM, Ostland VE, Pennington MW, Norton RS and
Westerman ME (2005). Bass hepcidin synthesis, solution
structure, antimicrobial activities and synergism, and in
vivo hepatic response to bacterial infections. JBC., 280:
9272-9282.
Masso-Silva JA and Diamond G (2014). Antimicrobial
peptides from fish. Pharm., 7: 265-310.
Matsuzaki K, (1999). Why and how are peptide–lipid
interactions utilized for self-defense? Magainins and
tachyplesins as archetypes. Biochim. Biophys. Acta,
Biomembr., 1462: 1-10.
Miyakawa Y, Ratnakar P, Rao AG, Costello ML, MathieuCostello O, Lehrer RI and Catanzaro A (1996). In vitro
activity of the antimicrobial peptides human and rabbit
defensins and porcine leukocyte protegrin against
Mycobacterium tuberculosis. Infect. Immun., 64: 926-932.
Nguyen LT, Haney EF and Vogel HJ (2011). The expanding
scope of antimicrobial peptide structures and their modes
of action. Trends Biotechnol., 29: 464-472.
Powers JPS and Hancock RE (2003). The relationship
between peptide structure and antibacterial activity.
Peptides., 24: 1681-1691.
Ramón-García S, Mikut R, Ng C, Ruden S, Volkmer R,
Reischl M, Hilpert K and Thompson CJ (2013).
Targeting Mycobacterium tuberculosis and other
microbial pathogens using improved synthetic
antibacterial peptides. AAC., 57: 2295-2303.
Reddy KVR, Yedery RD and Aranha C (2004). Antimicrobial
peptides: premises and promises. Int. J. Antimicrob.
Agents., 24: 536-547.
Reinhardt A (2017). Antimicrobial peptides as new potential
antibiotics (Doctoral dissertation, Universität zu Köln).
Sathyan N and Philip R (2015). Molecular and Functional
Characterization of Histone Derived Antimicrobial
Peptides from Marine Organisms (Doctoral dissertation,
Cochin University of Science and Technology).
Steiner H (1982). Secondary structure of the cecropins:
antibacterial peptides from the moth Hyalophora
cecropia. FEBS., 137: 283-287.
Steinstraesser L. Kraneburg U, Jacobsen F and Al-Benna S
(2011). Host defense peptides and their antimicrobialimmunomodulatory duality. Immunobiol., 216: 322-333.
Tincu JA and Taylor SW (2004). Antimicrobial peptides from
marine invertebrates. AAC., 48: 3645-3654.
Valero Y, Saraiva‐Fraga M, Costas B and Guardiola FA
(2020). Antimicrobial peptides from fish: Beyond the fight
against pathogens. Rev. Aquac., 12: 224-253.
Wiesner J and Vilcinskas A (2010). Antimicrobial peptides:
the ancient arm of the human immune system. Virulence.,
1: 440-464.
Willey JM and Van Der Donk WA (2007). Lantibiotics:
peptides of diverse structure and function. Ann. Rev.
Microbiol., 61: 477-501.
Yeaman MR and Yount NY (2003). Mechanisms of
antimicrobial peptide action and resistance. Pharmacol.
Rev., 55: 27-55.
Yılmaz S, Ergün S, Yiğit M and Yılmaz E (2022). An
extensive review on the use of feed additives against fish
diseases and improvement of health status of fish in
Turkish aquaculture sector. Aquacu. Studies., 22: 710.
Zeya HI and Spitznagel JK (1963). Antibacterial and
enzymic basic proteins from leukocyte lysosomes:
separation and identification. Sci., 142: 1085-1087.
Volume 1, Issue 1
June 2024
Pages 37-40

  • Receive Date 09 April 2024
  • Revise Date 20 May 2024
  • Accept Date 20 May 2024